Mutational Advantage 
Instant
$6.90 #2008 0.45 2.5 years
Permanents you control with counters on them gain hexproof and indestructible until end of turn. Prevent all damage that would be dealt to those permanents this turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)
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Cards similar to Mutational Advantage expected a card that isn't here?
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Heroic Intervention91%
$8.29↑#30↑0.90↑9.6 years↑
"Permanents you control gain hexproof and indestructible until end of turn."
Tamiyo's Safekeeping86%
$5.06↓#476↑0.31↓4.5 years↑
"Target permanent you control gains hexproof and indestructible until end of turn. You gain 2 life."
Restoration Magic84%
$2.58↓#1135↑0.29↓1.2 years↓
"• Curaga — 
— Permanents you control gain hexproof and indestructible until end of turn. You gain 6 life."
— Permanents you control gain hexproof and indestructible until end of turn. You gain 6 life."
Avacyn, Angel of Hope84%
$29.08↑#769↑1.35↑14.4 years↑
"Other permanents you control have indestructible."
Defend the Rider82%
$0.74↓#3397↓0.24↓1.6 years
"• Target permanent you control gains hexproof and indestructible until end of turn."
Ultimate Magic: Holy81%
$0.44↓#2752↓0.451.2 years↓
"Permanents you control gain indestructible until end of turn. If this spell was cast from exile, prevent all damage that would be dealt to you this turn."
Soul of New Phyrexia78%
$0.54↓#3458↓0.17↓12.1 years↑
"
: Permanents you control gain indestructible until end of turn."
: Permanents you control gain indestructible until end of turn."
Invisible Force Field78%
$0.33↓#15698↓0.00↓0.2 years↓
"Up to four target permanents you control gain indestructible until end of turn."
Blacksmith's Skill77%
$0.32↓#22860.22↓5.2 years↑
"Target permanent gains hexproof and indestructible until end of turn. If it's an artifact creature, it gets +2/+2 until end of turn."
Restricted Office // Lecture Hall76%
$0.20↓#5234↓0.27↓1.9 years
"Other permanents you control have hexproof."
Blinding Fog76%
$0.15↓#10465↓0.60↑8.9 years↑
"Prevent all damage that would be dealt to creatures this turn. Creatures you control gain hexproof until end of turn."
Dawn's Truce75%
$4.60↓#354↑0.432.1 years
"You and permanents you control gain hexproof until end of turn. If the gift was promised, permanents you control also gain indestructible until end of turn."
Avabruck Caretaker // Hollowhenge Huntmaster74%
$4.47↓#7413↓0.86↑4.8 years↑
"Other permanents you control have hexproof."
Sigarda, Font of Blessings74%
$3.69↓#3327↓0.56↑3.3 years
"Other permanents you control have hexproof."
Bulwark Ox74%
$0.30↓#7021↓0.18↓1.6 years
"Sacrifice this creature: Creatures you control with counters on them gain hexproof and indestructible until end of turn."
Tyrant Guard73%
$4.81↓#5764↓0.80↑3.9 years↑
"Sacrifice this creature: Creatures you control with counters on them gain hexproof and indestructible until end of turn."
Privileged Position73%
$1.68↓#3305↓0.66↑20.9 years↑
"Other permanents you control have hexproof."
Join Shields72%
$0.20↓#15743↓0.09↓7.9 years↑
"Untap all creatures you control. They gain hexproof and indestructible until end of turn."
Bofur, Reliable Guardian // Concerted Care72%
$0.27↓#11481↓0.00↓0.1 years↓
"Target artifact or creature you control gains hexproof and indestructible until end of turn."
Flare of Fortitude72%
$4.34↓#739↑0.71↑2.2 years
"Until end of turn, your life total can't change, and permanents you control gain hexproof and indestructible."